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Hypoism Issues

Role of Dopamine in Addiction Causation

Theory of Addiction - Hypoism Hypothesis

Why drug use is unconscious and against one's willfulness - not volitional

Misuse of the word choice in addictions



What Am I Angry About? - Don't Ask Me This Again

Disease Concept - A Perspective


Page Directory of this Site with Explanations and Links

The History of the Proof of Hypoism in the Wake of the P/R Paradigm page 1.

History page 2

Why Addiction Experts and Other People Are Ignoring Hypoism

Strange Brew


The Paradigm Vacuum in Addictions Today


What Does An Addiction Expert Know?

The Hypoism Addiction Hypothesis - An Evolutionary Psychology Perspective

Addiction Questionnaire

Misconceptions of addictions and addicts

What's Hypoism? What's an Addiction?


Why We Need Hypoism: A Comparison of the Principles and Consequences between the two Paradigms

Entitled to Your Opinion? Not Anymore.

HYPOICMAN: A non-recovering, unimpressed Hypoic

The Field of Addictionology: A Golfing Analogy


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Hypoism Treatment Research

The Addiction Treatment Fraud Finally Exposed

Hypoism Treatment Research Proposal



The National Association for the Advancement and Advocacy of Addicts

Make A Contribution To The N4A

Addict Discrimination Documentation

Social Innovations Award 2000 for The N4A

Third Millennium N4A Conference Keynote Address on Hypoism - Pathophysiology in Addictions vs. Superstition

N4A Goes on the Offensive - Suggesting Real Action

The Verdict

Blind Faith?

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Opening Statement

Chapter 1

Vision For The Future

Outcomes of Hypoic's Handbook


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Harm reduction prototype: Swiss PROVE program

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The Phoenix Magazine

Hypoics Not-Anonymous

Hypoics Not-Anonymous

Things You Can Do

What you can do---

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Addiction Genetics

Recent Genetic Studies on Various Addictions from a Large Twin Registry

Genetic Studies page 2.

Gateway theory finally disproven

Celera Discovers Millions of Tiny Genetic Differences in People

Interesting Addiction Science

Clinically Important Neurotransmitter Deficiencies

Hypoism Magazine-Articles by and for Hypoics


#1 Hatred, #2 The Words: Opinion, Belief, and Knowledge, #3 Hate Addiction

#4 The Drug War War, #5 Evolution vs. Creationism Revisited for Addictions

#6 American Society for Addiction Medicine Statement for Recovering Physicians

#7 Issues Peculiar to the Disease of Addictions

#8 Critique of Alan Lechner's (NIH), "The Hijacked Brain Hypothesis."

#8a. Update!! Dr. Leshner recently makes a change

#9 MY STORY - The Doctor Drug War - Wrong and Wasteful p.1, 1/6/00

The Doctor Drug War p.2

Doctor Drug War p.3

Doctor Drug War p.4

Doctor Drug War p.5

Affidavit for judicial review of NYS Dept. of Ed.

#10 The Superstition Instinct 3/1/00

#11-Conflict of Interest in Addiction Research

#12 - Controlled Drinking Lands On Its Ass

#13 - The Kennedy Curse or Kennedy Hypoism?

#14 - The Lord's Prayer for Hypoics

#15 - Replacing Alan Leshner is the only way to end the Drug War

#16 - The Brain Addiction Mechanism and the COGA Study

#17 - Letter to the director of the National Academy of Medicine's Board on Neurobiology and Behavior Health on Addictions

#18 - Is Addiction Voluntary, A Choice, as Leshner and NIDA Insist?

#19 - Bush's Alcoholism and Lies

#20 - A P/R Paradigm Addict - "Cured?"

#21 - Congress Misled and Lied to by NIAAA

#22 - Special Letter to the Times on Addiction Genetics

#23 - JAMA Editor Publishes According to His Beliefs, Not Science

#24 - Smoking as Gateway Drug. I Don't Think So!


#25 - One Less Heroin Addict. But At What Cost?

#26 - An Open Letter to the Judge who Sentences Robert Downey, Jr.

#27 - Letter To Schools About The Pride Program Against Drugs

#28 - A Letter To Bill Moyers, Close To Home, and PBS


#30 - Brookhaven Labs Provide More Evidence For Hypoism

#31 - Addiction Prevention Revisited


#33 - NIDA Is Close But No Cigar

#34 - Bush's Addict Discrimination and Hypocricy Begins

#35 - Maya Angelou's, "Still I Rise."

#36 - Leshner Lies To Congress

#37 - Addiction Combos

#38 Brain tumor proves Hypoism hypothesis

#39: So-called Availability Debunked as Contributor of Addictions

#40 - Hypoism Reproduced By A Pill



The Hypoism Blog - The Addiction Blog

The Addiction Blog 4/17/11 -

The Addiction Blog 9/14/10 - 4/16/11

The Addiction Blog 11/12/09 - 9/14/10

The Addiction Blog 7/23/09 - 11/09/09

The Addiction Blog 5/16/09 - 7/22/09

The Addiction Blog 3/3/09 - 5/13/09

The Addiction Blog 8/3/08 - 3/3/09

The Addiction Blog 4/1/07 - 8/3/08

old letters

My NY Times Letters to the Editor page 1.

My NY Times Letters to the Editor page 2.

My NY Times Letters to the Editor page 3.

My NY Times Letters to the Editor page 4.

My NY Times Letters to the Editor page 5.

My New York Times Letters to the Editor page 6.

My Letters to the editor of the NY Times page 7.

My Letters to the Editor of the NY Times page 8.

NY Times Letters Page 9.

New York Times Letters Page 10

My NYT Letters page 11

NY Times Letters page 12.

NY Times letters p. 13

Letters to the NY Times page 14.

Letters to Newsday

Letters To The Los Angeles Times

Creationism/Evolution Letter to BAM 11-25-05


Committee for Physician Health Speech

The Future of Addictions

Addict Discrimination in the News

Mandated Treatment for Welfare Recipients

Anorectic Murdered by Doctors out of Ignorance and "Desperation"(10/20/99)

Six Dead Heroin Addicts-Enough? 10/31/99

American Society of Addiction Medicine Discrimination

Darryl Strawberry Punished Again

South Carolina Forces Pregnant Women to Take Drug Tests

When it comes to drugs, the constitution doesn't apply

Parents of Overweight Girl Will Sue New Mexico



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Hypoics are born, not made.

Dan F. Umanoff, M.D.  
8779 Misty Creek Dr.  
Sarasota, Florida 34241  




Like it or not there’s an inescapable logic to the Hypoism paradigm. You may not like the paradigm or its outcomes, but to dispute it you must dispute the logic, period. Thus, anyone who denies this logic has the responsibility to argue and disprove the following logic, piece by piece. This must be the basis of any debate about the cause of addictions.

Using drugs (legal, illegal, and alcohol) as the prototype addictor, the logic is as follows (I footnote individual arguments that need expanding that will appear at the end of the paper):

  • Many people use drugs but only a small percentage get addicted. This shows the cause of addictions is in the person not the drug.
  • Addictions to specific drugs all have high heritability[i]. This means that addictions are mostly and possibly completely genetic.
  • That addictions are genetic means there must be some mechanism in the body causing addictions and that specific genes and their alleles work within that mechanism to cause addictions. This means there is a mechanism present in everyone from which addictions originate and the genes that cause addictions work within this mechanism, and only those people with the correct genes or alleles of these genes will get addicted.
  • Some genes or their alleles cause addictions to certain addictors and others to other addictors. This means there are two simultaneous issues here: 1) general addictability, plus 2) specific addictions to specific addictors[ii].
  • All drugs of addiction act within the reward center of the brain as natural neurotransmitter substitutes, and most likely elsewhere as well. This means that the mechanism that causes drug addictions includes the reward system[iii].
  • The evolutionary (enhanced survival) purpose for the reward system and that of the larger brain mechanism that utilizes the reward system within it are the reasons this brain mechanism exists. How this mechanism works and where it is located in the brain are the reasons why it causes addictions and other symptoms of Hypoism when effected by the low activity of the specific allelic genes working within this mechanism. These unusual and unique behaviors must be explained and dictated by the actual function of this brain mechanism, a brain mechanism that evolved to handle specific survival functions, instincts. Hypoism explains why addictions are not freely made choices, but are inexorable and unconscious decisions that overwhelm conscious decision-making, the unexplained paradox of the current addiction paradigms.
  • The understanding of the brain mechanism that causes addictions must explain and dictate all addictions[iv] as well as the treatment, prevention, and public policies of addictions[v]. Self-explanatory.
  • It turns out that the particular brain mechanism we are dealing with here is what I have called “The Decision-Making apparatus,” the instinct regulating system derived via human evolution over hundreds of millions of years. The alterations of this brain mechanism by the genes and their alleles must explain all characteristics of the paradigm[vi]. The Hypoism paradigm.
  • It turns out that it does. How do we know? All addictions are explained by this one system as they must for the addiction paradigm to be valid. They all include either 1) addictions to natural neurotransmitter substitutes, drugs (act like the endogenous reward neurotransmitters within the mechanism) or, 2) addictions to specific instincts (behavioral addictions). Thus, the origins and the characteristics of all addictions are fully explained by genetic alterations of this one brain mechanism[vii]. Only Hypoism does this.
  • Any addiction paradigm must reconcile all of the above including the mechanism of recovery and relapse. Hypoism is the only current addiction paradigm that does this. Thus, Hypoism must replace all other addiction paradigms until some other one does it better. Moreover, prevention, treatment, and public policy must be derived from this paradigm as well.
  • Similarly, if one is going to dispute Hypoism, one must dispute these points, one by one. To date, no one has accepted this paradigmatic challenge, a very telling fact concerning all other addiction paradigms.

[i] The heritability argument, including general addictability as well as specific addictor addictions: Heritability is a complex epidemiological genetic concept much misused by the addiction experts. For example: if an epidemiologist studies “alcoholism” in a population and finds 60% heritability, then says “alcoholism is 60% genetic and thus 40% environmental (by default),” this is incorrect. The correct conclusion is really, “alcoholism is at least 60% genetic and the other 40% can still be genetic and/or environmental in etiology,” because if one studies heritability closely one sees that there are many genetic factors and principles left out of this particular epidemiological tool. Proof of an environmental role in the etiology of addictions can’t be derived from heritability studies. And that has been the problem in the past and present in assigning an environmental role in addiction etiology; that it has. Proof that environment has some role in etiology must come from other types of studies. These studies have never been done. Thus, the belief that addictions are caused by both genetics and environmental causes as derived from epidemiological studies is absolutely false and knowingly a lie. There is no proof, yet it is “accepted.” To reiterate: there is plenty of proof that addictions are mostly genetic in etiology but no proof at all that environment has any etiological role. In fact, if you read my book and articles about this stuff you will see that I specifically state that addictability is completely genetic but addictions to specific addictors may have environmental influences. In other words, for one to be an addict of any kind one must have the correct genetics (Hypoism), but the specific addictions (symptoms), which addictor one uses and gets addicted to,  may be influenced by environmental issues such as availability, past experiences, peer influences, etc. as well as genetic issues, the specific alleles of specific genes one has inherited. This statement is completely different from stating, “addictions have been shown to be etiologically partly genetic and partly environmental.”

For a review of the best epidemiological studies, although they continue to make the above mistakes without discussing or admitting the nuances of the term heritability, read: http://www.nvo.com/hypoism/recentgeneticstudiesonvariousaddictionsfromalargetwinregistr/



For a review of the term heritability, read any recent Genetics textbook.

[ii] General addictability has yet to be studied as an entity, but the data from the COGA study could be looked at to delineate this trait. One such report from the COGA study is: Laura Jean Bierut, MD; Stephen H. Dinwiddie, MD; Henri Begleiter, MD; Raymond R. Crowe, MD; Victor Hesselbrock, PhD; John I. Nurnberger, Jr, MD, PhD; Bernice Porjesz, PhD; Marc A. Schuckit, MD; Theodore Reich, MD, Familial Transmission of Substance Dependence: Alcohol, Marijuana, Cocaine, and Habitual Smoking. A Report From the Collaborative Study on the Genetics of Alcoholism,  Arch Gen Psychiatry. 1998;55:982-988.  In addition, Goldman and others have delineated this concept in their writings: David Goldman, MD; Andrew Bergen, PhD General and Specific Inheritance of Substance Abuse and Alcoholism, Arch. Gen. Psych. Vol. 55 No. 11, November 1998. So far, however, no epidemiological studies on general addictability have been undertaken. My prediction is that they will show much higher heritability than for specific addictions, thus, adding more weight to the Hypoism paradigm.

[iii] Because the reward system subserves other brain mechanism(s), the other, larger, brain mechanism(s) must be the cause of addictions, not merely the reward center itself.

[iv] This brings into account “behavioral” addictions as being part and parcel of the same addiction paradigm.

[v] A general principle of all medical science.

[vi] Read: http://www.nvo.com/hypoism/thehypoismaddictionhypothesis/

[vii] Animal addiction studies over the last fifteen years all point to this.

You can take the addiction out of the hypoic, but you can't take the Hypoism out of the addict.

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