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Hypoism Issues

Role of Dopamine in Addiction Causation

Theory of Addiction - Hypoism Hypothesis

Why drug use is unconscious and against one's willfulness - not volitional

Misuse of the word choice in addictions



What Am I Angry About? - Don't Ask Me This Again

Disease Concept - A Perspective


Page Directory of this Site with Explanations and Links

The History of the Proof of Hypoism in the Wake of the P/R Paradigm page 1.

History page 2

Why Addiction Experts and Other People Are Ignoring Hypoism

Strange Brew


The Paradigm Vacuum in Addictions Today


What Does An Addiction Expert Know?

The Hypoism Addiction Hypothesis - An Evolutionary Psychology Perspective

Addiction Questionnaire

Misconceptions of addictions and addicts

What's Hypoism? What's an Addiction?


Why We Need Hypoism: A Comparison of the Principles and Consequences between the two Paradigms

Entitled to Your Opinion? Not Anymore.

HYPOICMAN: A non-recovering, unimpressed Hypoic

The Field of Addictionology: A Golfing Analogy


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Hypoism Treatment Research

The Addiction Treatment Fraud Finally Exposed

Hypoism Treatment Research Proposal



The National Association for the Advancement and Advocacy of Addicts

Make A Contribution To The N4A

Addict Discrimination Documentation

Social Innovations Award 2000 for The N4A

Third Millennium N4A Conference Keynote Address on Hypoism - Pathophysiology in Addictions vs. Superstition

N4A Goes on the Offensive - Suggesting Real Action

The Verdict

Blind Faith?

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Opening Statement

Chapter 1

Vision For The Future

Outcomes of Hypoic's Handbook


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Harm reduction prototype: Swiss PROVE program

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The Phoenix Magazine

Hypoics Not-Anonymous

Hypoics Not-Anonymous

Things You Can Do

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Addiction Genetics

Recent Genetic Studies on Various Addictions from a Large Twin Registry

Genetic Studies page 2.

Gateway theory finally disproven

Celera Discovers Millions of Tiny Genetic Differences in People

Interesting Addiction Science

Clinically Important Neurotransmitter Deficiencies

Hypoism Magazine-Articles by and for Hypoics


#1 Hatred, #2 The Words: Opinion, Belief, and Knowledge, #3 Hate Addiction

#4 The Drug War War, #5 Evolution vs. Creationism Revisited for Addictions

#6 American Society for Addiction Medicine Statement for Recovering Physicians

#7 Issues Peculiar to the Disease of Addictions

#8 Critique of Alan Lechner's (NIH), "The Hijacked Brain Hypothesis."

#8a. Update!! Dr. Leshner recently makes a change

#9 MY STORY - The Doctor Drug War - Wrong and Wasteful p.1, 1/6/00

The Doctor Drug War p.2

Doctor Drug War p.3

Doctor Drug War p.4

Doctor Drug War p.5

Affidavit for judicial review of NYS Dept. of Ed.

#10 The Superstition Instinct 3/1/00

#11-Conflict of Interest in Addiction Research

#12 - Controlled Drinking Lands On Its Ass

#13 - The Kennedy Curse or Kennedy Hypoism?

#14 - The Lord's Prayer for Hypoics

#15 - Replacing Alan Leshner is the only way to end the Drug War

#16 - The Brain Addiction Mechanism and the COGA Study

#17 - Letter to the director of the National Academy of Medicine's Board on Neurobiology and Behavior Health on Addictions

#18 - Is Addiction Voluntary, A Choice, as Leshner and NIDA Insist?

#19 - Bush's Alcoholism and Lies

#20 - A P/R Paradigm Addict - "Cured?"

#21 - Congress Misled and Lied to by NIAAA

#22 - Special Letter to the Times on Addiction Genetics

#23 - JAMA Editor Publishes According to His Beliefs, Not Science

#24 - Smoking as Gateway Drug. I Don't Think So!


#25 - One Less Heroin Addict. But At What Cost?

#26 - An Open Letter to the Judge who Sentences Robert Downey, Jr.

#27 - Letter To Schools About The Pride Program Against Drugs

#28 - A Letter To Bill Moyers, Close To Home, and PBS


#30 - Brookhaven Labs Provide More Evidence For Hypoism

#31 - Addiction Prevention Revisited


#33 - NIDA Is Close But No Cigar

#34 - Bush's Addict Discrimination and Hypocricy Begins

#35 - Maya Angelou's, "Still I Rise."

#36 - Leshner Lies To Congress

#37 - Addiction Combos

#38 Brain tumor proves Hypoism hypothesis

#39: So-called Availability Debunked as Contributor of Addictions

#40 - Hypoism Reproduced By A Pill



The Hypoism Blog - The Addiction Blog

The Addiction Blog 4/17/11 -

The Addiction Blog 9/14/10 - 4/16/11

The Addiction Blog 11/12/09 - 9/14/10

The Addiction Blog 7/23/09 - 11/09/09

The Addiction Blog 5/16/09 - 7/22/09

The Addiction Blog 3/3/09 - 5/13/09

The Addiction Blog 8/3/08 - 3/3/09

The Addiction Blog 4/1/07 - 8/3/08

old letters

My NY Times Letters to the Editor page 1.

My NY Times Letters to the Editor page 2.

My NY Times Letters to the Editor page 3.

My NY Times Letters to the Editor page 4.

My NY Times Letters to the Editor page 5.

My New York Times Letters to the Editor page 6.

My Letters to the editor of the NY Times page 7.

My Letters to the Editor of the NY Times page 8.

NY Times Letters Page 9.

New York Times Letters Page 10

My NYT Letters page 11

NY Times Letters page 12.

NY Times letters p. 13

Letters to the NY Times page 14.

Letters to Newsday

Letters To The Los Angeles Times

Creationism/Evolution Letter to BAM 11-25-05


Committee for Physician Health Speech

The Future of Addictions

Addict Discrimination in the News

Mandated Treatment for Welfare Recipients

Anorectic Murdered by Doctors out of Ignorance and "Desperation"(10/20/99)

Six Dead Heroin Addicts-Enough? 10/31/99

American Society of Addiction Medicine Discrimination

Darryl Strawberry Punished Again

South Carolina Forces Pregnant Women to Take Drug Tests

When it comes to drugs, the constitution doesn't apply

Parents of Overweight Girl Will Sue New Mexico



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Hypoics are born, not made.

Dan F. Umanoff, M.D.  
8779 Misty Creek Dr.  
Sarasota, Florida 34241  



As recently discussed in an editorial in the New England Journal of Medicine and reiterated in an interview on NPR’s Weekend All Things Considered (listen to the interview with "real player" at the link on the web page called "special links to important web sites" on the left border pages menu), Marcia Angell, editor-in-chief of the journal, discusses how business interests (drug companies, and treatment industries such as device manufacturers) influence medical research. I include her editorial below. One issue she inadvertently left out of this discussion is the conflict of interest in research of various forms of "therapy" used in so-called psychological and psychiatric entities. This form of conflict of interest is not perceived as biased by medical industry because it is done by thousands of individual treatment "professionals." Nonetheless, this group of individual therapists is an enormous industry desiring research rationale for their jobs and "treatments." Researchers for this group of therapists and rehab hospitals are under the same financial influences as researchers for drug and medical device companies. The same conflict of interest rules Dr. Angell calls for in the case of The New England Journal should be seen as relevant to this industry as well, including their journals, where peer review is deeply suspect. Of course, these rules don't apply to them to the detriment of all addicts who are often coerced into these bogus treatments by the beneficiaries of those treatments, so-called "treatment providers."
Listen to the interview as Dr. Angell mentions the emphasis on drug treatments instead of research into cause of disease as well as non-drug treatments. Read the editorial (below) and then explore on your own the conflicts of interest involving practically all addiction research being done and published in our country today. See who’s supporting the National Council on Alcoholism and Drug Dependence (NCADD), the Long Island Council on Alcoholism (or other local councils), the only existing watch dogs addicts have to protect them from research and treatment bias. These groups are more concerned with their funding than with the addictions and addicts they profess to support. For example, when I recently called the NCADD, one of the routing extensions went directly to the American Society of Addiction Medicine.
Moreover, the U.S. government, clearly biased by its own addiction paradigm and need to control addictions, funds 85% of the country's drug addiction research according to Alan Leshner, head of NIH's National Institute on Drugs and Alcoholism. Much of this funding is aimed at finding drugs and programs to control addicts rather than to help them. Additionally, various massive health oriented foundations are funding research that promote their personal views on addictions. These entities buy scientists and research companies to do their specified research. The researcher's and business's financial well being is determined by their producing the required results. You tell me that there's no conflict of interest here. Peer review is additionally done by biased "experts" involved in the same conflicts of interest and lucrative treatment modalities, not hardly disinterested scientists!
Lastly, media outlets such as newspapers, TV news and magazine shows, magazines for public consumption, and publishing houses concoct programs and publish books and stories according to their biases and conflicts of interest. Two good examples of this were the shows by 20/20 on alcoholism and PBS's Bill Moyers special on addictions, both biased and way off base, yet highly influential to public opinion. Conflict of interest is one of our major problems.


In 1984 the Journal became the first of the major medical journals to require authors of original research articles to disclose any financial ties with companies that make products discussed in papers submitted to us. (1) We were aware that such ties were becoming fairly common, and we thought it reasonable to disclose them to readers. Although we came to this issue early, no one could have foreseen at the time just how ubiquitous and manifold such financial associations would become. The article by Keller et al. (2) in this issue of the Journal provides a striking example. The authors' ties with companies that make antidepressant drugs were so extensive that it would have used too much space to disclose them fully in the Journal. We decided merely to summarize them and to provide the details on our Web site.

Finding an editorialist to write about the article presented another problem. Our conflict-of-interest policy for editorialists, established in 1990, (3) is stricter than that for authors of original research papers. Since editorialists do not provide data, but instead selectively review the literature and offer their judgments, we require that they have no important financial ties to companies that make products related to the issues they discuss. We do not believe disclosure is enough to deal with the problem of possible bias. This policy is analogous to the requirement that judges recuse themselves from hearing cases if they have financial ties to a litigant. Just as a judge's disclosure would not be sufficiently reassuring to the other side in a court case, so we believe that a policy of caveat emptor is not enough for readers who depend on the opinion of editorialists.

But as we spoke with research psychiatrists about writing an editorial on the treatment of depression, we found very few who did not have financial ties to drug companies that make antidepressants. (Fortunately, Dr. Jan Scott, who is eminently qualified to write the editorial, (4) met our standards with respect to conflicts of interest.) The problem is by no means unique to psychiatry. We routinely encounter similar difficulties in finding editorialists in other specialties, particularly those that involve the heavy use of expensive drugs and devices.

In this editorial, I wish to discuss the extent to which academic medicine has become intertwined with the pharmaceutical and biotechnology industries, and the benefits and risks of this state of affairs. Bodenheimer, in his Health Policy Report elsewhere in this issue of the Journal, (5) provides a detailed view of an overlapping issue -- the relations between clinical investigators and the pharmaceutical industry.

The ties between clinical researchers and industry include not only grant support, but also a host of other financial arrangements. Researchers serve as consultants to companies whose products they are studying, join advisory boards and speakers' bureaus, enter into patent and royalty arrangements, agree to be the listed authors of articles ghostwritten by interested companies, promote drugs and devices at company-sponsored symposiums, and allow themselves to be plied with expensive gifts and trips to luxurious settings. Many also have equity interest in the companies.

Although most medical schools have guidelines to regulate financial ties between their faculty members and industry, the rules are generally quite relaxed and are likely to become even more so. For some years, Harvard Medical School prided itself on having unusually strict guidelines. For example, Harvard has prohibited researchers from having more than $20,000 worth of stock in companies whose products they are studying. (6) But now the medical school is in the process of softening its guidelines. Those reviewing the Harvard policy claim that the guidelines need to be modified to prevent the loss of star faculty members to other schools. The executive dean for academic programs was reported to say, "I'm not sure what will come of the proposal. But the impetus is to make sure our faculty has reasonable opportunities." (7)

Academic medical institutions are themselves growing increasingly beholden to industry. How can they justify rigorous conflict-of-interest policies for individual researchers when their own ties are so extensive? Some academic institutions have entered into partnerships with drug companies to set up research centers and teaching programs in which students and faculty members essentially carry out industry research. Both sides see great benefit in this arrangement. For financially struggling medical centers, it means cash. For the companies that make the drugs and devices, it means access to research talent, as well as affiliation with a prestigious "brand." The time-honored custom of drug companies' gaining entry into teaching hospitals by bestowing small gifts on house officers has reached new levels of munificence. Trainees now receive free meals and other substantial favors from drug companies virtually daily, and they are often invited to opulent dinners and other quasi-social events to hear lectures on various medical topics. All of this is done with the acquiescence of the teaching hospitals.

What is the justification for this large-scale breaching of the boundaries between academic medicine and for-profit industry? Two reasons are usually offered, one emphasized more than the other. The first is that ties to industry are necessary to facilitate technology transfer -- that is, the movement of new drugs and devices from the laboratory to the marketplace. The term "technology transfer" entered the lexicon in 1980, with the passage of federal legislation, called the Bayh-Dole Act, (8) that encouraged academic institutions supported by federal grants to patent and license new products developed by their faculty members and to share royalties with the researchers. The Bayh-Dole Act is now frequently invoked to justify the ubiquitous ties between academia and industry. It is argued that the more contacts there are between academia and industry, the better it is for clinical medicine; the fact that money changes hands is considered merely the way of the world.

A second rationale, less often invoked explicitly, is simply that academic medical centers need the money. Many of the most prestigious institutions in the country are bleeding red ink as a result of the reductions in Medicare reimbursements contained in the 1997 Balanced Budget Act and the hard bargaining of other third-party payers to keep hospital costs down. Deals with drug companies can help make up for the shortfall, so that academic medical centers can continue to carry out their crucial missions of education, research, and the provision of clinical care for the sickest and neediest. Under the circumstances, it is not surprising that institutions feel justified in accepting help from any source.

I believe the claim that extensive ties between academic researchers and industry are necessary for technology transfer is greatly exaggerated, particularly with regard to clinical research. There may be some merit to the claim for basic research, but in most clinical research, including clinical trials, the "technology" is essentially already developed. Researchers are simply testing it. Furthermore, whether financial arrangements facilitate technology transfer depends crucially on what those arrangements are. Certainly grant support is constructive, if administered properly. But it is highly doubtful whether many of the other financial arrangements facilitate technology transfer or confer any other social benefit. For example, there is no conceivable social benefit in researchers' having equity interest in companies whose products they are studying. Traveling around the world to appear at industry-sponsored symposiums has much more to do with marketing than with technology transfer. Consulting arrangements may be more likely to further the development of useful products, but even this is arguable. Industry may ask clinical researchers to become consultants more to obtain their goodwill than to benefit from their expertise. The goodwill of academic researchers is a very valuable commodity for drug and device manufacturers. Finally, it is by no means necessary for technology transfer that researchers be personally rewarded. One could imagine a different system for accomplishing the same purpose. For example, income from consulting might go to a pool earmarked to support research or any other mission of the medical center.

What is wrong with the current situation? Why shouldn't clinical researchers have close ties to industry? One obvious concern is that these ties will bias research, both the kind of work that is done and the way it is reported. Researchers might undertake studies on the basis of whether they can get industry funding, not whether the studies are scientifically important. That would mean more research on drugs and devices and less designed to gain insights into the causes and mechanisms of disease. It would also skew research toward finding trivial differences between drugs, because those differences can be exploited for marketing. Of even greater concern is the possibility that financial ties may influence the outcome of research studies.

As summarized by Bodenheimer, (5) there is now considerable evidence that researchers with ties to drug companies are indeed more likely to report results that are favorable to the products of those companies than researchers without such ties. That does not conclusively prove that researchers are influenced by their financial ties to industry. Conceivably, drug companies seek out researchers who happen to be getting positive results. But I believe bias is the most likely explanation, and in either case, it is clear that the more enthusiastic researchers are, the more assured they can be of industry funding.

Many researchers profess that they are outraged by the very notion that their financial ties to industry could affect their work. They insist that, as scientists, they can remain objective, no matter what the blandishments. In short, they cannot be bought. What is at issue is not whether researchers can be "bought," in the sense of a quid pro quo. It is that close and remunerative collaboration with a company naturally creates goodwill on the part of researchers and the hope that the largesse will continue. This attitude can subtly influence scientific judgment in ways that may be difficult to discern. Can we really believe that clinical researchers are more immune to self-interest than other people?

When the boundaries between industry and academic medicine become as blurred as they now are, the business goals of industry influence the mission of the medical schools in multiple ways. In terms of education, medical students and house officers, under the constant tutelage of industry representatives, learn to rely on drugs and devices more than they probably should. As the critics of medicine so often charge, young physicians learn that for every problem, there is a pill (and a drug company representative to explain it). They also become accustomed to receiving gifts and favors from an industry that uses these courtesies to influence their continuing education. The academic medical centers, in allowing themselves to become research outposts for industry, contribute to the overemphasis on drugs and devices. Finally, there is the issue of conflicts of commitment. Faculty members who do extensive work for industry may be distracted from their commitment to the school's educational mission.

All of this is not to gainsay the importance of the spectacular advances in therapy and diagnosis made possible by new drugs and devices. Nor is it to deny the value of cooperation between academia and industry. But that cooperation should be at arm's length, with both sides maintaining their own standards and ethical norms. The incentives of the marketplace should not become woven into the fabric of academic medicine. We need to remember that for-profit businesses are pledged to increase the value of their investors' stock. That is a very different goal from the mission of medical schools.

What needs to be done -- or undone? Softening its conflict-of-interest guidelines is exactly the wrong thing for Harvard Medical School to do. Instead, it should seek to encourage other institutions to adopt stronger ones. If there were general agreement among the major medical schools on uniform and rigorous rules, the concern about losing faculty to more lax schools -- and the consequent race to the bottom -- would end. Certain financial ties should be prohibited altogether, including equity interest and many of the writing and speaking arrangements. Rules regarding conflicts of commitment should also be enforced. It is difficult to believe that full-time faculty members can generate outside income greater than their salaries without shortchanging their institutions and students.

As Rothman urges, teaching hospitals should forbid drug-company representatives from coming into the hospital to promote their wares and offer gifts to students and house officers. (9) House officers should buy their own pizza, and hospitals should pay them enough to do so. To the argument that these gifts are too inconsequential to constitute bribes, the answer is that the drug companies are not engaging in charity. These gifts are intended to buy the goodwill of young physicians with long prescribing lives ahead of them. Similarly, academic medical centers should be wary of partnerships in which they make available their precious resources of talent and prestige to carry out research that serves primarily the interests of the companies. That is ultimately a Faustian bargain.

It is well to remember that the costs of the industry-sponsored trips, meals, gifts, conferences, and symposiums and the honorariums, consulting fees, and research grants are simply added to the prices of drugs and devices. The Clinton administration and Congress are now grappling with the serious problem of escalating drug prices in this country. In these difficult times, academic medicine depends more than ever on the public's trust and goodwill. If the public begins to perceive academic medical institutions and clinical researchers as gaining inappropriately from cozy relations with industry -- relations that create conflicts of interest and contribute to rising drug prices -- there will be little sympathy for their difficulties. Academic institutions and their clinical faculty members must take care not to be open to the charge that they are for sale.

Marcia Angell, M.D.

You can take the addiction out of the hypoic, but you can't take the Hypoism out of the addict.

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